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By Dorothy C. Gosting

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L. Lesser. Effect of wheat fiber and vitamin C and vitamin E on rectal polyps in patients with familial adenomatous polyposis. J. Natl. Cancer last. 81:1290-1297 (1989). 145. Sinkeldam, E. , C. F. Kuper, M. C. Bosland, V. M. H. Hollanders and D. M. Vedder. Interactive effects of dietary wheat bran and lard on iV-methyl-W- 42 FOOD SAFETY 1990 nitro-7V-nitrosoguanicüne-induced colon carcinogenesis in rats. Cancer Res. 50:1092-1096 (1990). 146. Heitman, D. , V. A. Ord, K. E. Hunter and I. L. Cameron.

5 μιηοΐ. The most effective antimutagens included: the isoflavone, biochanin A; the flavanone glycoside, naringin, and its aglycone, naringenin; and several flavonols—morin, fisetin, kaempferol, gossypetin, quercetin, and rutin. Since MNNG does not require metabolic activation, it appears that these compounds act by preventing uptake of the carcinogen or by altering some cellular processes. The effects of the dietary flavonoids, chrysin, quercetin, flavone, and flavanone on several components of the rat liver drug-metabolizing enzyme system were examined and compared with those of two synthetic flavonoids, 7,8-benzoflavone and 5,6benzoflavone (180).

Inhibitory effect of butylated hydroxyanisole administration on pancreatic carcinogenesis in Syrian hamsters initiated with iV-nitrosobis(2-oxopropyl)amine. Carcinogenesis 10:1491-1494 (1989). 166. Lau, B. H. , P. P. Tadi and J. M. Tosk. Allium sativwn (garlic) and cancer prevention. Nutr. Res. 10:937948 (1990). 167. Hu, P-J. and M. J. Wargovich. Effect of diallyl sulfide on MNNG-induced nuclear aberrations and ornithine decarboxylase activity in the glandular stomach mucosa of the Wistar rat. Cancer Lett.

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