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By Kenneth R. Miller (Eds.)


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Continuously elevated levels of free calcium ions (shaded region) occur in the tail which contains both actin and myosin and is postulated to be the site of the force-generating contraction. The arrows indicate the direction of cytoplasmic streaming. N, nucleus; EN, solated endoplasm; EC, gelled ectoplasmic cortex. ) 28 ELIZABETH J. LUNA et al. Another obligatory step in cell locomotion may be a localized weakening of the cortex at the tip of an advancing pseudopod, perhaps signaled by the binding of a chemotactic agent.

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And Irvine. R . F. ) 3 / 2 : 315-321. Besterman, J. , and Low, R. B. (1983) Biochem. J . 210: 1-13. , and Bainton, D. F. (1981) Cell 24: 905-914. , and White. J. G. (1988) Science 239; 883-888. , Heath. J . , and Moss, D. (1986) J . Cell Sci. Suppl. 4: 71-88. Bretscher, M. S. (1983) Proc. Natl. Acad. Sci. USA 80: 4 5 4 4 5 8 . Bretscher, M. S. (1984) Science (Wash. DC) 224: 681-686. Brown, S. , and Petzold. A. S. (1987) J. Cell Biol. 104: 513-518. Burgess, D. R. (1987) Adv. Cell Biol. I : 31-58.

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